Solid tumors · ADC delivery

The first antibody-drug conjugate directed at 5T4 produced no objective responses across twenty-six patients and was stopped by ocular toxicity.1

Among nearly three thousand patients given ADCs for lung cancer, 30.9% experienced a pulmonary adverse event.2

261
patients, and no objective responses, in the first conjugate directed at 5T4
30.9%2
of patients given conjugates for lung cancer had a pulmonary adverse event

A target that has failed three times has either been disproved or never properly engineered. The evidence points at the second.

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